Publisher Summary The division of human immunoglobulin genes into various families was
initially obvious from the protein data, although it appears that significant portions of the
repertoire were missed by sequencing myeloma proteins. The reasons for this still remain
clouded. However, using molecular techniques, most of the gene families have now been
uncovered and their numbers, location, etc. are slowly being sorted out. A major surprise
has been the significant interdigitation of the human VH genes, considering the clustering of …