The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.
MJ Eck, M Ultsch, E Rinderknecht, AM De Vos… - Journal of Biological …, 1992 - ASBMB
The three-dimensional structure of recombinant human lymphotoxin (residues 24-171 of the
mature protein) has been determined by x-ray crystallography at 1.9-A resolution (Rcryst=
0.215 for I greater than 3 sigma (I)). Phases were derived by molecular replacement using
tumor necrosis factor (TNF-alpha) as a search model. Like TNF-alpha, lymphotoxin (LT)
folds to form a" jellyroll" beta-sheet sandwich. Three-fold related LT subunits form a trimer
stabilized primarily by hydrophobic interactions. A cluster of 6 basic residues around the 3 …
mature protein) has been determined by x-ray crystallography at 1.9-A resolution (Rcryst=
0.215 for I greater than 3 sigma (I)). Phases were derived by molecular replacement using
tumor necrosis factor (TNF-alpha) as a search model. Like TNF-alpha, lymphotoxin (LT)
folds to form a" jellyroll" beta-sheet sandwich. Three-fold related LT subunits form a trimer
stabilized primarily by hydrophobic interactions. A cluster of 6 basic residues around the 3 …
