Insulin action in the polycystic ovary syndrome

A Dunaif - Endocrinology and metabolism clinics of North America, 1999 - Elsevier
Polycystic ovary syndrome (PCOS) is an exceptionally common disorder of premenopausal
women characterized by hyperandrogenism and chronic anovulation. 10, 17 Its etiology
remains unknown. A recent population-based study has confirmed prevalence estimates
ranging from 5% to 10% in women of reproductive age. 29 Several rare syndromes of
hyperandrogenism and extreme insulin resistance are usually accompanied by the skin
lesion acanthosis nigricans. 10 It was first reported in 1980 that women with PCOS had …