Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins
YA Moon, NA Shah, S Mohapatra, JA Warrington… - Journal of Biological …, 2001 - ASBMB
Fatty acids are synthesized de novo from acetyl-CoA and malonyl-CoA through a series of
reactions mediated by acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). In
rodents, the principal fatty acid produced by FAS is palmitic acid (16: 0). Sterol regulatory
element-binding proteins (SREBPs) enhance the transcription of many genes responsible
for fatty acid synthesis. In transgenic mice that overexpress SREBPs in liver, the rate of fatty
acid synthesis is markedly increased, owing to the activation of these biosynthetic genes …
reactions mediated by acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). In
rodents, the principal fatty acid produced by FAS is palmitic acid (16: 0). Sterol regulatory
element-binding proteins (SREBPs) enhance the transcription of many genes responsible
for fatty acid synthesis. In transgenic mice that overexpress SREBPs in liver, the rate of fatty
acid synthesis is markedly increased, owing to the activation of these biosynthetic genes …
