The localization and expression of the renin–angiotensin system in the human placenta throughout pregnancy

AC Cooper, G Robinson, GP Vinson, WT Cheung… - Placenta, 1999 - Elsevier
All the components of the renin-angiotensin system (RAS), including the AT1receptor, have
previously been shown to be present in the human term placenta. However, the presence of
the RAS components has not been fully investigated in the human placenta throughout
pregnancy. The aim of this study was to examine the localization of the angiotensin
receptors AT1and AT2using immunocytochemistry and the expression of prorenin,
angiotensinogen and the AT1and AT2receptor mRNA using RT-PCR in the human placenta …