Development of the tight‐skin phenotype in immune‐deficient mice
TD Dodig, KT Mack, DF Cassarino… - Arthritis & …, 2001 - Wiley Online Library
TD Dodig, KT Mack, DF Cassarino, SH Clark
Arthritis & Rheumatism, 2001•Wiley Online LibraryObjective To determine if cutaneous thickening, a major phenotypic feature of the tight‐skin
(Tsk) mutation, could develop in an immune‐deficient mouse. Methods Experimental
crosses among different strains of mice were conducted to create mice that were genetically
Tsk/+, and that were also homozgyous for a mutation at the Prkdcscid locus and thus lacked
mature T and B lymphocytes. Skin samples prepared from experimental and control
genotypic groups of mice were evaluated for skin thickness. Results The data showed that …
(Tsk) mutation, could develop in an immune‐deficient mouse. Methods Experimental
crosses among different strains of mice were conducted to create mice that were genetically
Tsk/+, and that were also homozgyous for a mutation at the Prkdcscid locus and thus lacked
mature T and B lymphocytes. Skin samples prepared from experimental and control
genotypic groups of mice were evaluated for skin thickness. Results The data showed that …
Objective
To determine if cutaneous thickening, a major phenotypic feature of the tight‐skin (Tsk) mutation, could develop in an immune‐deficient mouse.
Methods
Experimental crosses among different strains of mice were conducted to create mice that were genetically Tsk/+, and that were also homozgyous for a mutation at the Prkdcscid locus and thus lacked mature T and B lymphocytes. Skin samples prepared from experimental and control genotypic groups of mice were evaluated for skin thickness.
Results
The data showed that the Tsk/+ mice developed the Tsk phenotype in the absence of a functional immune system.
Conclusion
Mature T and B cells are not required for the development of the cutaneous thickening in mice carrying the Tsk mutation.
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