[HTML][HTML] Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells
A Sapirstein, RA Spech, R Witzgall… - Journal of Biological …, 1996 - ASBMB
Phospholipase A 2 (PLA 2) and reactive oxygen species have been implicated both
individually and synergistically in various forms of cellular injury. The form (s) of PLA 2
important for cell injury and the implications of enhanced activity of the enzyme, however,
have not been discerned. Previous studies reveal an increase in PLA 2 activity associated
with cell injury, but this association does not establish a causal relationship between the
increase in activity and the injury. LLC-PK 1 cell lines were created that express either the …
individually and synergistically in various forms of cellular injury. The form (s) of PLA 2
important for cell injury and the implications of enhanced activity of the enzyme, however,
have not been discerned. Previous studies reveal an increase in PLA 2 activity associated
with cell injury, but this association does not establish a causal relationship between the
increase in activity and the injury. LLC-PK 1 cell lines were created that express either the …