[HTML][HTML] Cleavage and shedding of E-cadherin after induction of apoptosis
U Steinhusen, J Weiske, V Badock, R Tauber… - Journal of Biological …, 2001 - ASBMB
Apoptotic cell death induces dramatic molecular changes in cells, becoming apparent on the
structural level as membrane blebbing, condensation of the cytoplasm and nucleus, and
loss of cell-cell contacts. The activation of caspases is one of the fundamental steps during
programmed cell death. Here we report a detailed analysis of the fate of the Ca 2+-
dependent cell adhesion molecule E-cadherin in apoptotic epithelial cells and show that
during apoptosis fragments of E-cadherin with apparent molecular masses of 24, 29, and 84 …
structural level as membrane blebbing, condensation of the cytoplasm and nucleus, and
loss of cell-cell contacts. The activation of caspases is one of the fundamental steps during
programmed cell death. Here we report a detailed analysis of the fate of the Ca 2+-
dependent cell adhesion molecule E-cadherin in apoptotic epithelial cells and show that
during apoptosis fragments of E-cadherin with apparent molecular masses of 24, 29, and 84 …
