[HTML][HTML] The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid β-
protein (Aβ) identified the presenilins as important mediators of the γ-secretase cleavage of
β-amyloid precursor protein (APP). Recently, we found that two conserved transmembrane
(TM) aspartates in PS1 are critical for Aβ production, providing evidence that PS1 either
functions as a required diaspartyl cofactor for γ-secretase or is itself γ-secretase. Presenilin 2
(PS2) shares substantial sequence and possibly functional homology with PS1. Here, we …
protein (Aβ) identified the presenilins as important mediators of the γ-secretase cleavage of
β-amyloid precursor protein (APP). Recently, we found that two conserved transmembrane
(TM) aspartates in PS1 are critical for Aβ production, providing evidence that PS1 either
functions as a required diaspartyl cofactor for γ-secretase or is itself γ-secretase. Presenilin 2
(PS2) shares substantial sequence and possibly functional homology with PS1. Here, we …
