Inhibition of liver lipase in vivo leads to induction of de novo cholesterol synthesis in rat liver
H Jansen - Biochemical and biophysical research communications, 1985 - Elsevier
H Jansen
Biochemical and biophysical research communications, 1985•ElsevierRats were injected with control-γ-globulins or anti-liverlipase. The anti-liverlipase treatment
resulted in a 69–78% inhibition of the salt-resistant lipase activity (liver lipase) in the liver.
De novo cholesterol synthesis was significantly higher in slices of livers from anti-liverlipase
treated rats than from control-γ-globulin injected rats. The anti-liverlipase treatment also
affected all plasma lipoprotein fractions. If the rats had been fed a cholestyramine containing
diet no effect of anti-liverlipase on cholesterol synthesis was found. In these rats the effects …
resulted in a 69–78% inhibition of the salt-resistant lipase activity (liver lipase) in the liver.
De novo cholesterol synthesis was significantly higher in slices of livers from anti-liverlipase
treated rats than from control-γ-globulin injected rats. The anti-liverlipase treatment also
affected all plasma lipoprotein fractions. If the rats had been fed a cholestyramine containing
diet no effect of anti-liverlipase on cholesterol synthesis was found. In these rats the effects …
Abstract
Rats were injected with control-γ-globulins or anti-liverlipase. The anti-liverlipase treatment resulted in a 69–78% inhibition of the salt-resistant lipase activity (liver lipase) in the liver. De novo cholesterol synthesis was significantly higher in slices of livers from anti-liverlipase treated rats than from control-γ-globulin injected rats. The anti-liverlipase treatment also affected all plasma lipoprotein fractions. If the rats had been fed a cholestyramine containing diet no effect of anti-liverlipase on cholesterol synthesis was found. In these rats the effects on plasma lipoprotein fractions were more pronounced than in the control fed rats.
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