Genetic and environmental factors in cancer and neurodegenerative diseases

L Migliore, F Coppedè - Mutation Research/Reviews in Mutation Research, 2002 - Elsevier
The aim of this review is to summarise the recent findings in the fields of carcinogenesis and
neurodegenerative diseases, the both disorders are characterised by the contribution of
different factors including the inheritance of mutated genes, and the exposure to
endogenous or exogenous agents during the life. We first analysed the causative genes
until now discovered in both processes, then we focused our attention on the role of
environmental exposure, susceptibility factors, oxidative stress, apoptosis and aging to the …