Pathogenesis of membranous nephropathy
WG Couser, CK Abrass - Annual review of medicine, 1988 - annualreviews.org
WG Couser, CK Abrass
Annual review of medicine, 1988•annualreviews.orgMembranous nephropathy is the most common cause of idiopathic nephrotic syndrome in
adults. Recent studies of the pathogenesis of the sub-epithelial glomerular immune deposits
that characterize this disease have revealed new mechanisms of glomerular immune
deposit formation involving cell surface antigens and have documented the role of the C5b-9
membrane attack complex of complement in mediating renal injury. Understanding these
mechanisms may help us understand the pathogenesis of several other immune-mediated …
adults. Recent studies of the pathogenesis of the sub-epithelial glomerular immune deposits
that characterize this disease have revealed new mechanisms of glomerular immune
deposit formation involving cell surface antigens and have documented the role of the C5b-9
membrane attack complex of complement in mediating renal injury. Understanding these
mechanisms may help us understand the pathogenesis of several other immune-mediated …
Membranous nephropathy is the most common cause of idiopathic nephrotic syndrome in adults. Recent studies of the pathogenesis of the sub-epithelial glomerular immune deposits that characterize this disease have revealed new mechanisms of glomerular immune deposit formation involving cell surface antigens and have documented the role of the C5b-9 membrane attack complex of complement in mediating renal injury. Understanding these mechanisms may help us understand the pathogenesis of several other immune-mediated diseases and has implications for possible therapeutic interventions in MN.
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