[HTML][HTML] Regulation of μ-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site
J Kraus, C Börner, E Giannini, K Hickfang… - Journal of Biological …, 2001 - ASBMB
Morphine and the endogenous opioid peptide β-endorphin exert neuromodulatory as well
as immunomodulatory effects, which are transduced by μ-opioid receptors. In this report we
show that stimulation with interleukin-4 induces μ-opioid receptor transcripts in human
primary blood cells (T cells and polymorphonuclear leukocytes), immune cell lines (Raji, U-
937, and HMEC-1), and dendritic cells. In nonstimulated immune cells this gene is silent. In
addition, μ receptor transcription is up-regulated by interleukin-4 in cultures of primary rat …
as immunomodulatory effects, which are transduced by μ-opioid receptors. In this report we
show that stimulation with interleukin-4 induces μ-opioid receptor transcripts in human
primary blood cells (T cells and polymorphonuclear leukocytes), immune cell lines (Raji, U-
937, and HMEC-1), and dendritic cells. In nonstimulated immune cells this gene is silent. In
addition, μ receptor transcription is up-regulated by interleukin-4 in cultures of primary rat …
