Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
H Pircher, D Moskophidis, U Rohrer, K Bürki… - Nature, 1990 - nature.com
H Pircher, D Moskophidis, U Rohrer, K Bürki, H Hengartner, RM Zinkernagel
Nature, 1990•nature.comViruses persist in an immune population, as in the case of influenza, or in an individual, as
postulated for human immunodeficiency virus, when they are able to escape existent
neutralizing antibody responses by changing their antigens. It is now shown that viruses can
in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations
that alter the relevant T-cell epitope.
postulated for human immunodeficiency virus, when they are able to escape existent
neutralizing antibody responses by changing their antigens. It is now shown that viruses can
in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations
that alter the relevant T-cell epitope.
Abstract
Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.
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