[HTML][HTML] Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular …
M Gotthardt, M Trommsdorff, MF Nevitt, J Shelton… - Journal of Biological …, 2000 - ASBMB
The members of the low density lipoprotein (LDL) receptor gene family bind a broad
spectrum of extracellular ligands. Traditionally, they had been regarded as mere cargo
receptors that promote the endocytosis and lysosomal delivery of these ligands. However,
recent genetic experiments in mice have revealed critical functions for two LDL receptor
family members, the very low density lipoprotein receptor and the apoE receptor-2, in the
transmission of extracellular signals and the activation of intracellular tyrosine kinases. This …
spectrum of extracellular ligands. Traditionally, they had been regarded as mere cargo
receptors that promote the endocytosis and lysosomal delivery of these ligands. However,
recent genetic experiments in mice have revealed critical functions for two LDL receptor
family members, the very low density lipoprotein receptor and the apoE receptor-2, in the
transmission of extracellular signals and the activation of intracellular tyrosine kinases. This …