U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264. 7 cells into osteoclast-like cells
H Hotokezaka, E Sakai, K Kanaoka, K Saito… - Journal of Biological …, 2002 - ASBMB
Osteoclasts are multinucleated cells that differentiate from hematopoietic cells and possess
characteristics responsible for bone resorption. To study the involvement of mitogen-
activated protein kinases (MAPKs) in osteoclastogenesis of the murine monocytic cell line
RAW264. 7, which can differentiate into osteoclast-like cells in the presence of the receptor
activator of nuclear factor kappa B ligand (RANKL), we treated the cells with specific
inhibitors of p38 MAPK, PD169316 and SB203580, and specific inhibitors of MAPK …
characteristics responsible for bone resorption. To study the involvement of mitogen-
activated protein kinases (MAPKs) in osteoclastogenesis of the murine monocytic cell line
RAW264. 7, which can differentiate into osteoclast-like cells in the presence of the receptor
activator of nuclear factor kappa B ligand (RANKL), we treated the cells with specific
inhibitors of p38 MAPK, PD169316 and SB203580, and specific inhibitors of MAPK …
