PD-1: an inhibitory immunoreceptor involved in peripheral tolerance
H Nishimura, T Honjo - Trends in immunology, 2001 - cell.com
H Nishimura, T Honjo
Trends in immunology, 2001•cell.comPD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the
PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The
constitutive expression of PD-1 ligands (PD-L1 and PD-L2) on parenchymal cells of heart,
lung and kidney suggests that the PD-1–PD-L system could provide unique negative
signaling to help prevent autoimmune diseases.
PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The
constitutive expression of PD-1 ligands (PD-L1 and PD-L2) on parenchymal cells of heart,
lung and kidney suggests that the PD-1–PD-L system could provide unique negative
signaling to help prevent autoimmune diseases.
Abstract
PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The constitutive expression of PD-1 ligands (PD-L1 and PD-L2) on parenchymal cells of heart, lung and kidney suggests that the PD-1–PD-L system could provide unique negative signaling to help prevent autoimmune diseases.
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