Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans
L Glickstein, B Moore, T Bledsoe, N Damle… - Infection and …, 2003 - Am Soc Microbiol
L Glickstein, B Moore, T Bledsoe, N Damle, V Sikand, AC Steere
Infection and immunity, 2003•Am Soc MicrobiolIn a study of cytokine production ex vivo by Borrelia burgdorferi-stimulated peripheral blood
mononuclear cells from 27 patients with culture-positive erythema migrans, production of
inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree,
tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-
inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme
disease often induce a strong inflammatory response.
mononuclear cells from 27 patients with culture-positive erythema migrans, production of
inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree,
tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-
inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme
disease often induce a strong inflammatory response.
Abstract
In a study of cytokine production ex vivo by Borrelia burgdorferi-stimulated peripheral blood mononuclear cells from 27 patients with culture-positive erythema migrans, production of inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree, tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme disease often induce a strong inflammatory response.
American Society for Microbiology