Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression
AL Mellor, DH Munn - Annual review of immunology, 2000 - annualreviews.org
AL Mellor, DH Munn
Annual review of immunology, 2000•annualreviews.orgMammalian reproduction poses an immunological paradox because fetal alloantigens
encoded by genes inherited from the father should provoke responses by maternal T cells
leading to fetal loss. Current understanding of T cell immunobiology and the critical role of
inflammatory processes during pregnancy is reviewed and discussed. Lessons derived from
studies on the regulation of T cell responsiveness during mammalian gestation are
considered in the wider context of T cell tolerance toward some microbial infections and …
encoded by genes inherited from the father should provoke responses by maternal T cells
leading to fetal loss. Current understanding of T cell immunobiology and the critical role of
inflammatory processes during pregnancy is reviewed and discussed. Lessons derived from
studies on the regulation of T cell responsiveness during mammalian gestation are
considered in the wider context of T cell tolerance toward some microbial infections and …
Mammalian reproduction poses an immunological paradox because fetal alloantigens encoded by genes inherited from the father should provoke responses by maternal T cells leading to fetal loss. Current understanding of T cell immunobiology and the critical role of inflammatory processes during pregnancy is reviewed and discussed. Lessons derived from studies on the regulation of T cell responsiveness during mammalian gestation are considered in the wider context of T cell tolerance toward some microbial infections and tumors, avoidance of autoimmunity, and tissue allograft rejection.
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