[HTML][HTML] Ethanol regulates calcium channel subunits by protein kinase C δ-dependent and-independent mechanisms
HJ Walter, T McMahon, J Dadgar, D Wang… - Journal of Biological …, 2000 - ASBMB
Chronic exposure to ethanol increases the number of functional L-type voltage-gated
calcium channels in neural cells. In PC12 cells, this adaptive response is mediated by
protein kinase C δ (PKCδ), but the mechanisms by which this occurs are not known. Since
expression of several different calcium channel subunits can increase the abundance of
functional L-type channels, we sought to identify which subunits are regulated by ethanol.
Incubation of PC12 cells with 120–150 mm ethanol for 6 days increased levels of α 1C, α 2 …
calcium channels in neural cells. In PC12 cells, this adaptive response is mediated by
protein kinase C δ (PKCδ), but the mechanisms by which this occurs are not known. Since
expression of several different calcium channel subunits can increase the abundance of
functional L-type channels, we sought to identify which subunits are regulated by ethanol.
Incubation of PC12 cells with 120–150 mm ethanol for 6 days increased levels of α 1C, α 2 …