Endothelial injury and dysfunction in ischemic acute renal failure
BA Molitoris, R Sandoval, TA Sutton - Critical care medicine, 2002 - journals.lww.com
Ischemic acute renal failure is the most common cause of acute renal failure in hospitalized
patients and has an average mortality rate of 50%. Although epithelial and vascular smooth
muscle cell abnormalities have been clearly delineated in association with this condition, the
extent of endothelial injury and dysfunction has been difficult to document, primarily for
anatomic reasons. However, endothelial tight junction separation and endothelial cell
detachment, blebbing, and necrosis have been observed after ischemia in other organs. In …
patients and has an average mortality rate of 50%. Although epithelial and vascular smooth
muscle cell abnormalities have been clearly delineated in association with this condition, the
extent of endothelial injury and dysfunction has been difficult to document, primarily for
anatomic reasons. However, endothelial tight junction separation and endothelial cell
detachment, blebbing, and necrosis have been observed after ischemia in other organs. In …