[HTML][HTML] Structural divergence of human ghrelin: identification of multiple ghrelin-derived molecules produced by post-translational processing
H Hosoda, M Kojima, T Mizushima, S Shimizu… - Journal of Biological …, 2003 - ASBMB
Ghrelin, a novel 28-amino acid peptide with an n-octanoyl modification at Ser 3, was
isolated from rat stomach and found to be an endogenous ligand for the growth-hormone
secretagogue receptor (GHS-R). This octanoyl modification is essential for ghrelin-induced
GH release. We report here the purification and identification of human ghrelin from the
stomach, as well as structural analysis of the human ghrelin gene and quantitation of
changes in plasma ghrelin concentration before and after gastrectomy. Human ghrelin was …
isolated from rat stomach and found to be an endogenous ligand for the growth-hormone
secretagogue receptor (GHS-R). This octanoyl modification is essential for ghrelin-induced
GH release. We report here the purification and identification of human ghrelin from the
stomach, as well as structural analysis of the human ghrelin gene and quantitation of
changes in plasma ghrelin concentration before and after gastrectomy. Human ghrelin was …
