The detection of platelet-activating factor in inflamed human gingival tissue
K Noguchi, I Morita, S Murota - Archives of oral biology, 1989 - Elsevier
Abstract Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF) is a
biologically active lipid, like the prostaglandins, which mediates allergic and inflammatory
reactions. Aggregation of washed rabbit platelets was induced by a lipid prepared from
inflamed gingiva. The mobility of the active lipid was coincident with that of authentic PAF on
thin-layer chromatography. The aggregation was dose-dependent and inhibited by
pretreatment with a specific PAF antagonist, ONO 6240, but not by indomethacin or creatine …
biologically active lipid, like the prostaglandins, which mediates allergic and inflammatory
reactions. Aggregation of washed rabbit platelets was induced by a lipid prepared from
inflamed gingiva. The mobility of the active lipid was coincident with that of authentic PAF on
thin-layer chromatography. The aggregation was dose-dependent and inhibited by
pretreatment with a specific PAF antagonist, ONO 6240, but not by indomethacin or creatine …
