Phenomics, lipodystrophy, and the metabolic syndrome
RA Hegele - Trends in Cardiovascular Medicine, 2004 - Elsevier
The metabolic syndrome (MetS) is a common multiplex cluster of phenotypes strongly
related to cardiovascular disease that includes central obesity with hypertension,
dyslipidemia, and type 2 diabetes. The core molecular defect of the MetS is insulin
resistance; indeed, the terms “MetS” and “insulin resistance syndrome” often are used
interchangeably. The successful translation to clinical medicine of molecular genetic
research on other rare monogenic metabolic disorders has stimulated the evaluation of such …
related to cardiovascular disease that includes central obesity with hypertension,
dyslipidemia, and type 2 diabetes. The core molecular defect of the MetS is insulin
resistance; indeed, the terms “MetS” and “insulin resistance syndrome” often are used
interchangeably. The successful translation to clinical medicine of molecular genetic
research on other rare monogenic metabolic disorders has stimulated the evaluation of such …