Cyclic nucleotide phosphodiesterases: relating structure and function
SH Francis, IV Turko, JD Corbin - 2000 - Elsevier
Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of
cAMP and/or eGMP to produce the corresponding 5′-nucleotide. PDEs are critical
determinants for modulation of cellular levels of CAMP and/or eGMP by many stimuli. Eleven
families of PDEs with varying selectivities for cAMP or cGMP have been identified in
mammalian tissues. Within these families, multiple isoforms are expressed either as …
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of
cAMP and/or eGMP to produce the corresponding 5′-nucleotide. PDEs are critical
determinants for modulation of cellular levels of CAMP and/or eGMP by many stimuli. Eleven
families of PDEs with varying selectivities for cAMP or cGMP have been identified in
mammalian tissues. Within these families, multiple isoforms are expressed either as …