[HTML][HTML] Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine …
ML Ruehr, MA Russell, DG Ferguson, M Bhat… - Journal of Biological …, 2003 - ASBMB
Protein kinase A anchoring proteins (AKAPs) tether cAMP-dependent protein kinase (PKA)
to specific subcellular locations. The muscle AKAP, mAKAP, co-localizes with the
sarcoplasmic reticulum Ca 2+ release channel or ryanodine receptor (RyR). The purpose of
this study was to determine whether anchoring of PKA by mAKAP regulates RyR function.
Either mAKAP or mAKAP-P, which is unable to anchor PKA, was expressed in CHO cells
stably expressing the skeletal muscle isoform of RyR (CHO-RyR1). Immunoelectron …
to specific subcellular locations. The muscle AKAP, mAKAP, co-localizes with the
sarcoplasmic reticulum Ca 2+ release channel or ryanodine receptor (RyR). The purpose of
this study was to determine whether anchoring of PKA by mAKAP regulates RyR function.
Either mAKAP or mAKAP-P, which is unable to anchor PKA, was expressed in CHO cells
stably expressing the skeletal muscle isoform of RyR (CHO-RyR1). Immunoelectron …