[HTML][HTML] 5′-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three …
SA Hawley, MA Selbert, EG Goldstein… - Journal of Biological …, 1995 - ASBMB
AMP-activated protein kinase (AMPK) and Ca 2+/calmodulin (CaM)-dependent protein
kinase I (CaMKI) are protein kinases that are regulated both by allosteric activation (AMP
and Ca 2+/CaM, respectively) and by phosphorylation by upstream protein kinases (AMPK
kinase (AMPKK) and CaMKI kinase (CaMKIK), respectively). We now report that AMPKK can
activate CaMKI and that, conversely, CaMKIK can activate AMPK. CaMKIK is 68-fold more
effective at activating CaMKI than AMPK, while AMPKK is 17-fold more effective at activating …
kinase I (CaMKI) are protein kinases that are regulated both by allosteric activation (AMP
and Ca 2+/CaM, respectively) and by phosphorylation by upstream protein kinases (AMPK
kinase (AMPKK) and CaMKI kinase (CaMKIK), respectively). We now report that AMPKK can
activate CaMKI and that, conversely, CaMKIK can activate AMPK. CaMKIK is 68-fold more
effective at activating CaMKI than AMPK, while AMPKK is 17-fold more effective at activating …