Effect of prostaglandin E1 and its biosynthesis inhibitor indomethacin on drinking in the rat
MFP Guaita, E Chiaraviglio - Pharmacology Biochemistry and Behavior, 1980 - Elsevier
In the rat, injection of prostaglandin E 1 (PGE 1) 0.5, 1.0 or 2.0 μg into the 3rd brain ventricle
(3rd bv) inhibited the water deprivation-induced water intake in a dose-related fashion. The
1.0 μg dose of PGE 1 also inhibited the intake of 1.8% sodium chloride in rats depleted of
body sodium by intraperitoneal dialysis, and of food in food deprived rats during a 60 min
test period. Prostaglandin E 1 (1 μg) depressed the dipsogenic effect of angiotensin II (AII) or
carbachol injected through the same cannula. Water-deprived rats pretreated with the PG …
(3rd bv) inhibited the water deprivation-induced water intake in a dose-related fashion. The
1.0 μg dose of PGE 1 also inhibited the intake of 1.8% sodium chloride in rats depleted of
body sodium by intraperitoneal dialysis, and of food in food deprived rats during a 60 min
test period. Prostaglandin E 1 (1 μg) depressed the dipsogenic effect of angiotensin II (AII) or
carbachol injected through the same cannula. Water-deprived rats pretreated with the PG …