The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol
and the risk of coronary heart disease, the protection of susceptible animals from
atherosclerosis by transgenic manipulation of HDL metabolism, and several potentially anti-
atherogenic in vitro-properties have made HDL metabolism an interesting target for
pharmacological intervention in atheroslcerosis. We have previously reviewed the concept
of reverse cholesterol transport, which describes both the metabolism and the classic anti …