Eat dirt—the hygiene hypothesis and allergic diseases
ST Weiss - New England journal of medicine, 2002 - Mass Medical Soc
New England journal of medicine, 2002•Mass Medical Soc
There has been an epidemic of both autoimmune diseases (in which the immune response
is dominated by type 1 helper T [Th1] cells, such as type 1 diabetes, Crohn's disease, and
multiple sclerosis) and allergic diseases (in which the immune response is dominated by
type 2 helper T [Th2] cells, such as asthma, allergic rhinitis, and atopic dermatitis), as
documented in the article by Bach in this issue of the Journal. 1 The occurrence of these
diseases is higher in more affluent, Western, industrialized countries. One theory proposed …
is dominated by type 1 helper T [Th1] cells, such as type 1 diabetes, Crohn's disease, and
multiple sclerosis) and allergic diseases (in which the immune response is dominated by
type 2 helper T [Th2] cells, such as asthma, allergic rhinitis, and atopic dermatitis), as
documented in the article by Bach in this issue of the Journal. 1 The occurrence of these
diseases is higher in more affluent, Western, industrialized countries. One theory proposed …
There has been an epidemic of both autoimmune diseases (in which the immune response is dominated by type 1 helper T [Th1] cells, such as type 1 diabetes, Crohn's disease, and multiple sclerosis) and allergic diseases (in which the immune response is dominated by type 2 helper T [Th2] cells, such as asthma, allergic rhinitis, and atopic dermatitis), as documented in the article by Bach in this issue of the Journal. 1 The occurrence of these diseases is higher in more affluent, Western, industrialized countries. One theory proposed to explain this increase in the prevalence of autoimmune and allergic diseases is . . .
The New England Journal Of Medicine