Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA
EE Sheets, RG Urban, CP Crum, ML Hedley… - American journal of …, 2003 - Elsevier
Objective: The purpose of this study was to evaluate the safety of the administration of a
bacterial expression plasmid encoding a 13 amino acid sequence that is highly homologous
with human papillomavirus E7 within poly (lactide-co-glycolide) microparticles (ZYC101) in
women with HLA A2+ antigen and persistent cervical intraepithelial neoplasia grade 2/3 and
human papillomavirus 16. Study Design: Fifteen women entered an institutional review
board–approved dose-escalating phase I study with the use of three levels of blood …
bacterial expression plasmid encoding a 13 amino acid sequence that is highly homologous
with human papillomavirus E7 within poly (lactide-co-glycolide) microparticles (ZYC101) in
women with HLA A2+ antigen and persistent cervical intraepithelial neoplasia grade 2/3 and
human papillomavirus 16. Study Design: Fifteen women entered an institutional review
board–approved dose-escalating phase I study with the use of three levels of blood …