Hepatitis C virus–like particles combined with novel adjuvant systems enhance virus-specific immune responses
M Qiao, K Murata, AR Davis, SH Jeong, TJ Liang - Hepatology, 2003 - Elsevier
We have previously described the generation of hepatitis C virus–like particles (HCV-LPs) in
insect cells and shown that immunization with HCV-LPs elicited both humoral and cellular
immune responses in mice. To further characterize the HCV-LPs as a vaccine candidate, we
evaluated the effects of adjuvant AS01B (monophosphoryl lipid A [MPL] and QS21), CpG
10105, and the combination of the 2 adjuvants on the immunogenicity of HCV-LPs in AAD
mice (transgenic for HLA-A2. 1). All HCV-LP–immunized mice (with or without adjuvant) …
insect cells and shown that immunization with HCV-LPs elicited both humoral and cellular
immune responses in mice. To further characterize the HCV-LPs as a vaccine candidate, we
evaluated the effects of adjuvant AS01B (monophosphoryl lipid A [MPL] and QS21), CpG
10105, and the combination of the 2 adjuvants on the immunogenicity of HCV-LPs in AAD
mice (transgenic for HLA-A2. 1). All HCV-LP–immunized mice (with or without adjuvant) …