[HTML][HTML] Heat induction of the unphosphorylated form of hypoxia-inducible factor-1α is dependent on heat shock protein-90 activity
DM Katschinski, L Le, D Heinrich, KF Wagner… - Journal of Biological …, 2002 - ASBMB
Hypoxia-inducible factor (HIF)-1α is the oxygen-sensitive subunit of HIF-1, a transcriptional
master regulator of oxygen homeostasis. Oxygen-dependent prolyl hydroxylation targets HIF-
1α for ubiquitinylation and proteasomal degradation. Unexpectedly, we found that exposing
mice to elevated temperatures resulted in a strong HIF-1α induction in kidney, liver, and
spleen. To elucidate the molecular mechanisms responsible for this effect, HepG2 hepatoma
cells were exposed to different temperatures (34–42° C) under normoxic (20% O 2) or …
master regulator of oxygen homeostasis. Oxygen-dependent prolyl hydroxylation targets HIF-
1α for ubiquitinylation and proteasomal degradation. Unexpectedly, we found that exposing
mice to elevated temperatures resulted in a strong HIF-1α induction in kidney, liver, and
spleen. To elucidate the molecular mechanisms responsible for this effect, HepG2 hepatoma
cells were exposed to different temperatures (34–42° C) under normoxic (20% O 2) or …