[HTML][HTML] Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup
H Wang, W Ma, L Tejada, H Zhang, JD Morrow… - Journal of Biological …, 2004 - ASBMB
Cyclooxygenase-2 (COX-2), an inducible rate-limiting enzyme in prostaglandin
biosynthesis, is implicated in various physiological and pathological processes including
female fertility, renal function, angiogenesis, inflammation, and tumorigenesis. We showed
previously that targeted deletion of Ptgs2 encoding COX-2, but not Ptgs1 encoding COX-1,
in C57BL/6J/129 mice produces complete female infertility resulting from multiple
reproductive failures spanning ovulation, fertilization, and implantation. Here we show that …
biosynthesis, is implicated in various physiological and pathological processes including
female fertility, renal function, angiogenesis, inflammation, and tumorigenesis. We showed
previously that targeted deletion of Ptgs2 encoding COX-2, but not Ptgs1 encoding COX-1,
in C57BL/6J/129 mice produces complete female infertility resulting from multiple
reproductive failures spanning ovulation, fertilization, and implantation. Here we show that …