Concordant in situ and in vitro data show that maternal cigarette smoking negatively regulates placental cytotrophoblast passage through the cell cycle☆
O Genbacev, MT McMaster, J Lazic, S Nedeljkovic… - Reproductive …, 2000 - Elsevier
Maternal cigarette smoking is associated with fetal growth restriction and other pregnancy
complications. To investigate possible mechanisms involving the placenta, we studied the
morphology of first trimester chorionic villi from mothers who smoked. In mothers who
smoked> 20 cigarettes/day, floating villi showed focal defects including an absence of
cytotrophoblast stem cells and an abnormal thinning of the syncytium. Anchoring villi
displayed a striking increase in the number of cytotrophoblast columns that failed to reach …
complications. To investigate possible mechanisms involving the placenta, we studied the
morphology of first trimester chorionic villi from mothers who smoked. In mothers who
smoked> 20 cigarettes/day, floating villi showed focal defects including an absence of
cytotrophoblast stem cells and an abnormal thinning of the syncytium. Anchoring villi
displayed a striking increase in the number of cytotrophoblast columns that failed to reach …