Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels
Scavenger receptor class B, type I (SR-BI) is the high density lipoprotein (HDL) receptor
essential for hepatic uptake of HDL cholesterol. SR-BI was shown to impact plasma HDL
levels and be anti-atherogenic. Thus, the ability to regulate hepatic SR-BI may allow for the
modulation of plasma HDL cholesterol and progression of atherosclerosis. However,
regulation of SR-BI in liver is not well understood. Recently, the PDZ domain containing
protein PDZK1 was shown to interact with SR-BI and may serve an essential role in SR-BI …
essential for hepatic uptake of HDL cholesterol. SR-BI was shown to impact plasma HDL
levels and be anti-atherogenic. Thus, the ability to regulate hepatic SR-BI may allow for the
modulation of plasma HDL cholesterol and progression of atherosclerosis. However,
regulation of SR-BI in liver is not well understood. Recently, the PDZ domain containing
protein PDZK1 was shown to interact with SR-BI and may serve an essential role in SR-BI …
