Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates
H Shike, C Shimizu, X Lauth, JC Burns - Developmental & Comparative …, 2004 - Elsevier
Hepcidin is an antimicrobial peptide and iron-regulatory molecule that is conserved among
vertebrates. Mutations or over-expression of the human hepcidin gene have been found in
patients with hemochromatosis and refractory anemia. To further understand the function
and regulation of hepcidin, animal models are needed. We sequenced cDNA, genes and
upstream regions of zebrafish hepcidin and analyzed gene expression by kinetic PCR.
Zebrafish hepcidin genes consist of two introns and three exons that encode a …
vertebrates. Mutations or over-expression of the human hepcidin gene have been found in
patients with hemochromatosis and refractory anemia. To further understand the function
and regulation of hepcidin, animal models are needed. We sequenced cDNA, genes and
upstream regions of zebrafish hepcidin and analyzed gene expression by kinetic PCR.
Zebrafish hepcidin genes consist of two introns and three exons that encode a …
