[HTML][HTML] Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
GD Kamphaus, PC Colorado, DJ Panka… - Journal of Biological …, 2000 - ASBMB
We isolated and identified an endogenous 24-kDa human basement membrane-derived
inhibitor of angiogenesis and tumor growth, termed canstatin. Canstatin, a fragment of the α2
chain of type IV collagen, was produced as a recombinant molecule inEscherichia coli and
293 embryonic kidneys cells. Canstatin significantly inhibited human endothelial cell
migration and murine endothelial cell tube formation. Additionally, canstatin potently
inhibited 10% fetal bovine serum-stimulated endothelial cell proliferation and induced …
inhibitor of angiogenesis and tumor growth, termed canstatin. Canstatin, a fragment of the α2
chain of type IV collagen, was produced as a recombinant molecule inEscherichia coli and
293 embryonic kidneys cells. Canstatin significantly inhibited human endothelial cell
migration and murine endothelial cell tube formation. Additionally, canstatin potently
inhibited 10% fetal bovine serum-stimulated endothelial cell proliferation and induced …