Ultralow-dose micronized 17β-estradiol and bone density and bone metabolism in older women: a randomized controlled trial
KM Prestwood, AM Kenny, A Kleppinger, M Kulldorff - Jama, 2003 - jamanetwork.com
ContextEstrogen therapy is known to prevent osteoporosis, but studies have shown that
conventional doses increase adverse events. Whether lower doses, one quarter of standard
treatment, prevent bone loss is not known. ObjectiveTo examine the effect of 3 years of
treatment with 0.25 mg/d of micronized 17β-estradiol on bone mineral density (BMD) and
bone turnover in healthy older postmenopausal women. Design, Setting, and
ParticipantsRandomized, double-blind, placebo-controlled trial conducted from July 24 …
conventional doses increase adverse events. Whether lower doses, one quarter of standard
treatment, prevent bone loss is not known. ObjectiveTo examine the effect of 3 years of
treatment with 0.25 mg/d of micronized 17β-estradiol on bone mineral density (BMD) and
bone turnover in healthy older postmenopausal women. Design, Setting, and
ParticipantsRandomized, double-blind, placebo-controlled trial conducted from July 24 …
