[HTML][HTML] Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport
MP Sajan, J Rivas, P Li, ML Standaert… - Journal of Biological …, 2006 - ASBMB
The role of atypical protein kinase C (aPKC) in insulin-stimulated glucose transport in
myocytes and adipocytes is controversial. Whereas studies involving the use of adenovirally
mediated expression of kinase-inactive aPKC in L6 myocytes and 3T3/L1 and human
adipocytes, and data from knock-out of aPKC in adipocytes derived from mouse embryonic
stem cells and subsequently derived adipocytes, suggest that aPKCs are required for insulin-
stimulated glucose transport, recent findings in studies of aPKC knockdown by small …
myocytes and adipocytes is controversial. Whereas studies involving the use of adenovirally
mediated expression of kinase-inactive aPKC in L6 myocytes and 3T3/L1 and human
adipocytes, and data from knock-out of aPKC in adipocytes derived from mouse embryonic
stem cells and subsequently derived adipocytes, suggest that aPKCs are required for insulin-
stimulated glucose transport, recent findings in studies of aPKC knockdown by small …