Identification of a novel A20-binding inhibitor of nuclear factor-κB activation termed ABIN-2
S Van Huffel, F Delaei, K Heyninck, D De Valck… - Journal of Biological …, 2001 - ASBMB
The nuclear factor κB (NF-κB) plays a central role in the regulation of genes implicated in
immune responses, inflammatory processes, and apoptotic cell death. The zinc finger
protein A20 is a cellular inhibitor of NF-κB activation by various stimuli and plays a critical
role in terminating NF-κB responses. The underlying mechanism for NF-κB inhibition by A20
is still unknown. A20 has been shown to interact with several proteins including tumor
necrosis factor (TNF) receptor-associated factors 2 and 6, as well as the inhibitory protein of …
immune responses, inflammatory processes, and apoptotic cell death. The zinc finger
protein A20 is a cellular inhibitor of NF-κB activation by various stimuli and plays a critical
role in terminating NF-κB responses. The underlying mechanism for NF-κB inhibition by A20
is still unknown. A20 has been shown to interact with several proteins including tumor
necrosis factor (TNF) receptor-associated factors 2 and 6, as well as the inhibitory protein of …