[HTML][HTML] Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain
O Kim, J Yang, Y Qiu - Journal of Biological Chemistry, 2002 - ASBMB
Etk/Bmx is a member of the Btk family tyrosine kinase, which contains an N-terminal
pleckstrin homology domain. Etk has been shown to play a pivotal role in the regulation of
various cellular processes including differentiation, apoptosis, and cell motility. Here we
present evidence that Etk is a modulator of the small GTPase RhoA. Etk and RhoA both are
translocated to the plasma membrane and can form a complex upon serum stimulation in
C2C12 cells. Etk interacts with RhoA but not other closely related small GTPases such as …
pleckstrin homology domain. Etk has been shown to play a pivotal role in the regulation of
various cellular processes including differentiation, apoptosis, and cell motility. Here we
present evidence that Etk is a modulator of the small GTPase RhoA. Etk and RhoA both are
translocated to the plasma membrane and can form a complex upon serum stimulation in
C2C12 cells. Etk interacts with RhoA but not other closely related small GTPases such as …