Effect of NG-nitro-L-arginine on shock induced by endotoxin and by platelet activating factor in dogs
K Takekoshi, K Kasai, Y Suzuki, Y Sekiguchi… - European journal of …, 1993 - Elsevier
K Takekoshi, K Kasai, Y Suzuki, Y Sekiguchi, N Banba, T Nakamura, SI Shimoda
European journal of pharmacology, 1993•ElsevierWhen N G-nitro-l-arginine, a nitric oxide synthase inhibitor, administration was started 5 min
prior to shock induction in anesthetized dogs, a partial restoration was observed in
endotoxin-induced shock and a complete recovery in platelet activating factor (PAF)-induced
shock. When N G-nitro-l-arginine infusion was started 5 min after shock induction, no
significant recovery was observed in endotoxin-induced shock and a complete recovery in
PAF-induced shock. These data indicate that enhanced production of nitric oxide by …
prior to shock induction in anesthetized dogs, a partial restoration was observed in
endotoxin-induced shock and a complete recovery in platelet activating factor (PAF)-induced
shock. When N G-nitro-l-arginine infusion was started 5 min after shock induction, no
significant recovery was observed in endotoxin-induced shock and a complete recovery in
PAF-induced shock. These data indicate that enhanced production of nitric oxide by …
When N G-nitro-l-arginine, a nitric oxide synthase inhibitor, administration was started 5 min prior to shock induction in anesthetized dogs, a partial restoration was observed in endotoxin-induced shock and a complete recovery in platelet activating factor (PAF)-induced shock. When N G-nitro-l-arginine infusion was started 5 min after shock induction, no significant recovery was observed in endotoxin-induced shock and a complete recovery in PAF-induced shock. These data indicate that enhanced production of nitric oxide by vascular endothelial cells may contribute to endotoxin-or PAF-induced shock and also that some mediators including inducible nitric oxide synthase and/or cellular damage might be involved in endotoxin-induced shock.
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