The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides
M Gencik, S Meller, S Borgmann, T Sitter… - Clinical …, 2000 - Elsevier
Wegener granulomatosis (WG), microscopic polyangiitis (MP), and Churg Strauss syndrome
(CSS) are rare systemic autoimmune disorders. Common features are anti-neutrophil
cytoplasmic antibodies (ANCA) in patient sera. Whereas WG patients show mainly anti-
proteinase 3 ANCA, MP and CSS patients typically present anti-myeloperoxidase (MPO)
ANCA. ANCA play an important role in the pathogenesis in the vessel wall by activating
polymorphonuclear cells (PMN) and increased adhesivity between PMN and endothelial …
(CSS) are rare systemic autoimmune disorders. Common features are anti-neutrophil
cytoplasmic antibodies (ANCA) in patient sera. Whereas WG patients show mainly anti-
proteinase 3 ANCA, MP and CSS patients typically present anti-myeloperoxidase (MPO)
ANCA. ANCA play an important role in the pathogenesis in the vessel wall by activating
polymorphonuclear cells (PMN) and increased adhesivity between PMN and endothelial …