In vivo” depletion of macrophages by liposome-mediated “suicide
N van Rooijen, E van Kesteren-Hendrikx - Methods in enzymology, 2003 - Elsevier
Publisher Summary Macrophages are multifunctional cell and play a key role in natural and
acquired host defense reactions, in homeostasis, and in the regulation of numerous
biological processes. The main tools used are phagocytosis followed by intracellular
digestion and production and release of soluble mediators, such as cytokines, chemokines,
and nitric oxide (NO). Macrophages can be found as resident cells in all organs of the body,
and they can be recruited to sites of inflammation. The depletion of macrophages followed …
acquired host defense reactions, in homeostasis, and in the regulation of numerous
biological processes. The main tools used are phagocytosis followed by intracellular
digestion and production and release of soluble mediators, such as cytokines, chemokines,
and nitric oxide (NO). Macrophages can be found as resident cells in all organs of the body,
and they can be recruited to sites of inflammation. The depletion of macrophages followed …