Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE
CL Vanderlugt, NJ Karandikar, DJ Lenschow… - Journal of …, 1997 - Elsevier
PLP139–151-induced experimental autoimmune encephalomyelitis in the SJL mouse is a
Th1-mediated inflammatory demyelinating disease characterized by a relapsing–remitting
clinical course (R-EAE). Clinical relapses are mediated by T cells specific for a non-cross
reactive secondary PLP epitope (PLP178–191) induced by epitope spreading. We have
previously shown that B7-1 expression is upregulated in SJL mice undergoing R-EAE and in
vivo treatment during remission with F (ab) fragments of anti-B7-1 mAb, blocked epitope …
Th1-mediated inflammatory demyelinating disease characterized by a relapsing–remitting
clinical course (R-EAE). Clinical relapses are mediated by T cells specific for a non-cross
reactive secondary PLP epitope (PLP178–191) induced by epitope spreading. We have
previously shown that B7-1 expression is upregulated in SJL mice undergoing R-EAE and in
vivo treatment during remission with F (ab) fragments of anti-B7-1 mAb, blocked epitope …