Stimulation of inducible nitric oxide synthase by monosodium urate crystals in macrophages and expression of iNOS in gouty arthritis
L Chen, MS Hsieh, HC Ho, YH Liu, DT Chou, SH Tsai - Nitric Oxide, 2004 - Elsevier
From the studies on the involvement of iNOS in arthritis, it is clear that attention has focused
primarily on rheumatoid arthritis (RA) and osteoarthritis (OA). To date, little is known about
the role of iNOS in the pathophysiology of gouty arthritis (GA). Here, we investigated the
significance of iNOS expression in cell culture system as well as in GA patients. Gouty
crystals monosodium urate (MSU) appeared to up-regulate inducible nitric oxide synthase
(iNOS) mRNA and protein expression in a concentration-and time-dependent manner in …
primarily on rheumatoid arthritis (RA) and osteoarthritis (OA). To date, little is known about
the role of iNOS in the pathophysiology of gouty arthritis (GA). Here, we investigated the
significance of iNOS expression in cell culture system as well as in GA patients. Gouty
crystals monosodium urate (MSU) appeared to up-regulate inducible nitric oxide synthase
(iNOS) mRNA and protein expression in a concentration-and time-dependent manner in …