The calcium-binding protein S100A12 induces neutrophil adhesion, migration, and release from bone marrow in mouse at concentrations similar to those found in …
P Rouleau, K Vandal, C Ryckman, PE Poubelle… - Clinical …, 2003 - Elsevier
We investigated the proinflammatory activities of S100A12 in the context of synovial
inflammation. S100A12 levels were increased in the synovial fluids and plasma of patients
with gout, rheumatoid arthritis, psoriatic arthritis, and undetectable in osteoarthritis, a
noninflammatory disorder. S100A12 proved to induce neutrophil adhesion to fibrinogen via
Mac-1 at concentrations similar to those found in the synovial fluids. Similar concentrations
induced the recruitment of large numbers of neutrophils and monocytes in the murine air …
inflammation. S100A12 levels were increased in the synovial fluids and plasma of patients
with gout, rheumatoid arthritis, psoriatic arthritis, and undetectable in osteoarthritis, a
noninflammatory disorder. S100A12 proved to induce neutrophil adhesion to fibrinogen via
Mac-1 at concentrations similar to those found in the synovial fluids. Similar concentrations
induced the recruitment of large numbers of neutrophils and monocytes in the murine air …