An impairment of barrier size and charge selectivity of glomerular basement membrane in streptozotocin-induced diabetes and prevention by pharmacological therapy
S Isogai, K Mogami, H Ouchi, G Yoshino - Medical Electron Microscopy, 2000 - Springer
S Isogai, K Mogami, H Ouchi, G Yoshino
Medical Electron Microscopy, 2000•SpringerWe examined barrier size (pore size) and charge selectivity (anionic sites) of the glomerular
basement membrane (GBM) in experimental diabetes. For estimation of the pore size we
employed a new method, tissue negative staining. In diabetic rats, enlarged pores and
decreased numbers of anionic sites of GBM were observed. Both insulin treatment and
angiotensin-converting enzyme inhibitors prevented these changes. The renoprotective
effect of the two drugs is discussed in the article.
basement membrane (GBM) in experimental diabetes. For estimation of the pore size we
employed a new method, tissue negative staining. In diabetic rats, enlarged pores and
decreased numbers of anionic sites of GBM were observed. Both insulin treatment and
angiotensin-converting enzyme inhibitors prevented these changes. The renoprotective
effect of the two drugs is discussed in the article.
Abstract
We examined barrier size (pore size) and charge selectivity (anionic sites) of the glomerular basement membrane (GBM) in experimental diabetes. For estimation of the pore size we employed a new method, tissue negative staining. In diabetic rats, enlarged pores and decreased numbers of anionic sites of GBM were observed. Both insulin treatment and angiotensin-converting enzyme inhibitors prevented these changes. The renoprotective effect of the two drugs is discussed in the article.
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