Targeted delivery of anti-CTLA-4 antibody downregulates T cell function in vitro and in vivo
S Rao, C Vasu, O Martinez, S Kaithamana… - Clinical …, 2001 - Elsevier
CTLA-4 is a T cell surface molecule that binds to the costimulatory molecules CD80 and
CD86 on antigen-presenting cells and downregulates T cell function. Therefore, we wanted
to test whether antigen-specific activated T cells could be inhibited through directed CTLA-4
signaling using a bispecific antibody (BiAb) capable of simultaneously binding to CTLA-4
and a tissue-specific antigen. The BiAb was prepared by linking two separate monoclonal
antibodies against CTLA-4 and the thyroid-stimulating hormone receptor (TSHR). The …
CD86 on antigen-presenting cells and downregulates T cell function. Therefore, we wanted
to test whether antigen-specific activated T cells could be inhibited through directed CTLA-4
signaling using a bispecific antibody (BiAb) capable of simultaneously binding to CTLA-4
and a tissue-specific antigen. The BiAb was prepared by linking two separate monoclonal
antibodies against CTLA-4 and the thyroid-stimulating hormone receptor (TSHR). The …